Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 143-146.doi: 10.3969/j.issn.1673-8225.2011. 01.032

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Development of mechanical mechanisms of stem cells

Bao Zhi-qiang1, Ren Ming-ji1, Li Jian-fu2    

  1. 1Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot  010059, Inner Mongolia Autonomous Region, China
    2Department of Plastic Surgery, Southwest Hospital, Third Military Medical University of Chinese PLA, Chongqing  400038, China
  • Received:2010-08-26 Revised:2010-09-30 Online:2011-01-01 Published:2011-01-01
  • Contact: Ren Ming-ji, Professor, Master’s supervisor, Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Inner Mongolia Autonomous Region, China mingjir@sina.com
  • About author:Bao Zhi-qiang★, Studying for master’s degree, Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Inner Mongolia Autonomous Region, China baozhiqiang110@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30570708

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Abstract:

BACKGROUND: Recently, studies addressing molecular basis of various cell signal transduction and regulation mechanism of relevant functions have obtained important progress, but the biological behavior of stem cells is complicated. The related signal transduction pathway and mechanism of proliferation and differentiation remain unclear.
OBJECTIVE: To review relevant literatures, and to summarize the present status and application prospect of stem cell related signal pathway affected by cytomechanics.
METHODS: China National Knowledge Infrastructure and PubMed database were retrieved by computer for articles concerning mechanical effect of mechanisms for stem cells published from 2005 to 2010. The key words were “stem cell, signal transduction” or “stem cell, stress”. The articles on signal transduction pathway of stem cells published recently in the same field or published in the authorized journals were selected, and totally 179 articles were primarily selected. Finally, 33 articles were included in accordance with inclusion criteria.
RESULTS AND CONCLUSION: Many different signal pathways had been involved in the proliferation and differentiation of stem cells. The stem cells could play an important role in the stem appreciation and differentiation which were modulated by several different signal pathways, including F-actin, Ca2+, MAPK, Wnt and Notch. The exact mechanism of mechanics signal transduction and gene expression under stress condition will be an important content in future stem cell research.

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